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The ovine SOX2 gene: sequence, chromosomal localization and gonadal expression
- Source :
- Gene, Gene, Elsevier, 1997, 189, pp.143-147
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- The SOX gene family consists of a large number of embryonically expressed genes capable of encoding putative transcription factors and related by a DNA-binding domain, the HMG-box. We cloned and characterized the ovine SOX2 transcript using the screening of a testis (12dpp) cDNA library with a probe containing the SRY-HMG-box and we performed 3'RACE experiments. The ovine SOX2 sequence is strongly conserved in comparison to the human, mouse and chicken homologues and is located on sheep chromosome 1q33. The SOX2 expression pattern in developing gonads is consistent with the hypothesis that this gene plays a role in the germ cell line.
- Subjects :
- Male
endocrine system
Molecular Sequence Data
Biology
03 medical and health sciences
0302 clinical medicine
HMGB Proteins
Testis
Genetics
medicine
Animals
Amino Acid Sequence
Cloning, Molecular
Gonads
Gene
Peptide sequence
Transcription factor
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
[SDV.GEN]Life Sciences [q-bio]/Genetics
0303 health sciences
Sheep
Base Sequence
EXPRESSION DU GENE
cDNA library
SOXB1 Transcription Factors
Nucleic acid sequence
Chromosome Mapping
Gene Expression Regulation, Developmental
Nuclear Proteins
Chromosome
General Medicine
BIOLOGIE MOLECULAIRE
Molecular biology
DNA-Binding Proteins
medicine.anatomical_structure
Genes
030220 oncology & carcinogenesis
embryonic structures
SOX gene family
Germ cell
Transcription Factors
Subjects
Details
- ISSN :
- 03781119 and 18790038
- Volume :
- 189
- Database :
- OpenAIRE
- Journal :
- Gene
- Accession number :
- edsair.doi.dedup.....8bbc3f92c368938a04483dd9ffcb15cd
- Full Text :
- https://doi.org/10.1016/s0378-1119(96)00782-2