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The ovine SOX2 gene: sequence, chromosomal localization and gonadal expression

Authors :
Hélène Hayes
Eric Pailhoux
Jacqueline Bezard
Laurence Gianquinto
Corinne Cotinot
Emmanuel Payen
Nathalie Le Pennec
Unité de biologie cellulaire et moléculaire
Institut National de la Recherche Agronomique (INRA)
Unité de recherche Génétique Biochimique et Cytogénétique (LGBC)
Unité de recherche Physiologie de la reproduction des mammifères domestiques, Nouzilly
Source :
Gene, Gene, Elsevier, 1997, 189, pp.143-147
Publication Year :
1997
Publisher :
Elsevier BV, 1997.

Abstract

The SOX gene family consists of a large number of embryonically expressed genes capable of encoding putative transcription factors and related by a DNA-binding domain, the HMG-box. We cloned and characterized the ovine SOX2 transcript using the screening of a testis (12dpp) cDNA library with a probe containing the SRY-HMG-box and we performed 3'RACE experiments. The ovine SOX2 sequence is strongly conserved in comparison to the human, mouse and chicken homologues and is located on sheep chromosome 1q33. The SOX2 expression pattern in developing gonads is consistent with the hypothesis that this gene plays a role in the germ cell line.

Details

ISSN :
03781119 and 18790038
Volume :
189
Database :
OpenAIRE
Journal :
Gene
Accession number :
edsair.doi.dedup.....8bbc3f92c368938a04483dd9ffcb15cd
Full Text :
https://doi.org/10.1016/s0378-1119(96)00782-2