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Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells
- Source :
- Frontiers in Immunology, Duhan, Vikas; Khairnar, Vishal; Kitanovski, Simo; Hamdan, Thamer A; Klein, Andrés D; Lang, Judith; Ali, Murtaza; Adomati, Tom; Bhat, Hilal; Friedrich, Sarah-Kim; Li, Fanghui; Krebs, Philippe; Futerman, Anthony H; Addo, Marylyn M; Hardt, Cornelia; Hoffmann, Daniel; Lang, Philipp A; Lang, Karl S (2021). Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells. Frontiers in immunology, 11, p. 607889. Frontiers Research Foundation 10.3389/fimmu.2020.607889
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (Itgae, CD103) as a new regulator of antiviral IFN-I production in a mouse model of vesicular stomatitis virus (VSV) infection. CD103 was specifically expressed by splenic conventional dendritic cells (cDCs) and limited IFN-I production in these cells during VSV infection. Mechanistically, CD103 suppressed AKT phosphorylation and mTOR activation in DCs. Deficiency in CD103 accelerated early IFN-I in cDCs and prevented death in VSV infected animals. In conclusion, CD103 participates in regulation of cDC specific IFN-I induction and thereby influences immune activation after VSV infection. OA Förderung 2021
- Subjects :
- Mice, 129 Strain
GWAS -- genome wide association screen -- Itgae -- CD103 -- vesicular stomatitis virus -- IFN-I -- AKT -- mTOR
Medizinische Fakultät » Universitätsklinikum Essen » Institut für Immunologie
viruses
Immunology
Medizin
chemical and pharmacologic phenomena
Receptor, Interferon alpha-beta
Virus Replication
Mice, Inbred AKR
Antigens, CD
Mice, Inbred NOD
ddc:570
Animals
GWAS
ddc:610
Phosphorylation
Cells, Cultured
Itgae
Original Research
Mice, Knockout
Mice, Inbred BALB C
Mice, Inbred C3H
genome wide association screen
TOR Serine-Threonine Kinases
AKT
hemic and immune systems
Dendritic Cells
Vesiculovirus
Immunity, Innate
Mice, Inbred C57BL
Disease Models, Animal
Fakultät für Biologie » Bioinformatics and Computational Biophysics
Mice, Inbred DBA
Host-Pathogen Interactions
Interferon Type I
CD103
IFN-I
mTOR
570 Life sciences
biology
vesicular stomatitis virus
Vesicular Stomatitis
Biologie
Integrin alpha Chains
Proto-Oncogene Proteins c-akt
Genome-Wide Association Study
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....8bb9291d8e8e03a820b76e246728fadc