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Impacts of Dosing Frequency of the Combination Rifampin-Streptomycin on Its Bactericidal and Sterilizing Activities against Mycobacterium ulcerans in Mice▿
- Publication Year :
- 2009
- Publisher :
- American Society for Microbiology (ASM), 2009.
-
Abstract
- Because of operational limitations, a significant proportion of the health centers at the peripheral level are able to provide treatment to Buruli ulcer patients with the combination rifampin (rifampicin)-streptomycin (RIF-STR) only five times weekly (5/7) instead of seven times weekly (7/7), as recommended. The objective of this experiment is to assess the impacts of various dosing frequencies of the combination on its bactericidal and sterilizing activities against Mycobacterium ulcerans in mice. The results demonstrate that the bactericidal activities did not differ significantly among five dosing frequencies of the combination, ranging from seven times to twice weekly, whereas the sterilizing activities differed widely. RIF-STR 7/7 was the only regimen that was able to sterilize the infection after 4 to 8 weeks of treatment; the sterilizing activities associated with reduced dosing frequencies were significantly diminished, and 8 weeks of 5/7 administration yielded a relapse rate greater than the generally accepted level of 5%. We recommend that the duration of treatment with 5/7 administration be prolonged beyond 8 weeks and that additional experiments with mice be carried out, with sufficient statistical power to compare the relapse rates of M. ulcerans infection between 8 weeks of 7/7 administration and 10 and 12 weeks of 5/7 administration of RIF-STR.
- Subjects :
- Buruli ulcer
medicine.drug_class
Antibiotics
Physiology
Mice
medicine
Animals
Pharmacology (medical)
Experimental Therapeutics
Dosing
Buruli Ulcer
Antibacterial agent
Pharmacology
Mice, Inbred BALB C
biology
Mycobacterium ulcerans
biology.organism_classification
medicine.disease
Anti-Bacterial Agents
Regimen
Infectious Diseases
Treatment Outcome
Streptomycin
Immunology
Drug Therapy, Combination
Female
Rifampin
Rifampicin
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8bad6c8598e308a855c61f11ba97b115