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Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency and skin disorders. Various cells including mast cells release Zn-containing granules when activated; however, the biological role of the released Zn is currently unclear. Here we report our findings that Zn transporter ZnT2 is required for the release of Zn from mast cells. In addition, we found that Zn and mast cells induce IL-6 production from inflammatory cells such as skin fibroblasts and promote wound healing, a process that involves inflammation. Zn induces the production of a variety of pro-inflammatory cytokines including IL-6 through signaling pathways mediated by the Zn receptor GPR39. Consistent with these findings, wound healing was impaired in mice lacking IL-6 or GPR39. Thus, our results show that Zn and mast cells play a critical role in wound healing through activation of the GPR39/IL-6 signaling axis.
- Subjects :
- 0301 basic medicine
Cell biology
Science
Immunology
Inflammation
Article
Cell Line
Receptors, G-Protein-Coupled
Mice
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Mast Cells
Receptor
Interleukin 6
Cation Transport Proteins
Cells, Cultured
Immunodeficiency
Wound Healing
Multidisciplinary
biology
Interleukin-6
Chemistry
Zn transporter
medicine.disease
030104 developmental biology
biology.protein
Medicine
medicine.symptom
Signal transduction
Wound healing
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....8ba9f662b9b9e1213f9bc1116597d530