IL28B gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated arthropathy

Authors :: Bárbara Brasil Santana
Antonio Carlos Rosário Vallinoto
Marluísa de Oliveira Guimarães Ishak
Rosimar Neris Martins Feitosa
Ricardo Ishak
Rita Catarina Medeiros Sousa
Keyla Santos Guedes de Sá
Tuane Carolina de Souza Ferreira
Luiz Fernando Almeida Machado
Cezar Augusto Muniz Caldas
Vânia Nakauth Azevedo
Source :: Cytokine. 77
Publication Year :: 2015
Abstract: The present study is the first investigation of the association between single nucleotide polymorphisms (SNPs – rs8099917, rs12979860 and rs8103142) of the IL28B gene and the development of human T-lymphotropic virus (HTLV)-associated arthropathy (HAA). Individuals with HAA exhibited low interleukin (IL) 6 (p

Subjects :: 0301 basic medicine
CD4-Positive T-Lymphocytes
Male
rs12979860
CD8-Positive T-Lymphocytes
Gastroenterology
Biochemistry
Gene Frequency
Genotype
Immunology and Allergy
education.field_of_study
Deltaretrovirus Infections
rs8103142
rs8099917
Hematology
Viral Load
Interleukin-10
medicine.anatomical_structure
HTLV-associated arthropathy
Host-Pathogen Interactions
Cytokines
Female
medicine.symptom
medicine.medical_specialty
T cell
Population
Immunology
Single-nucleotide polymorphism
Biology
Asymptomatic
Deltaretrovirus
Polymorphism, Single Nucleotide
03 medical and health sciences
Interferon-gamma
Th2 Cells
Internal medicine
medicine
Humans
Lymphocyte Count
education
Allele frequency
Molecular Biology
Alleles
Arthritis, Infectious
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukins
Haplotype
Th1 Cells
030104 developmental biology
Haplotypes
IL-28B
Interferons
CD8

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