Back to Search
Start Over
Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy
- Source :
- International Journal of Nanomedicine
- Publication Year :
- 2015
- Publisher :
- Informa UK Limited, 2015.
-
Abstract
- Regimen adherence, systemic toxicities, and limited drug penetrance to viral reservoirs are obstacles limiting the effectiveness of antiretroviral therapy (ART). Our laboratory’s development of the monocyte-macrophage-targeted long-acting nanoformulated ART (nanoART) carriage provides a novel opportunity to simplify drug-dosing regimens. Progress has nonetheless been slowed by cumbersome, but required, pharmacokinetic (PK), pharmacodynamics, and biodistribution testing. To this end, we developed a small magnetite ART (SMART) nanoparticle platform to assess antiretroviral drug tissue biodistribution and PK using magnetic resonance imaging (MRI) scans. Herein, we have taken this technique a significant step further by determining nanoART PK with folic acid (FA) decorated magnetite (ultrasmall superparamagnetic iron oxide [USPIO]) particles and by using SMART particles. FA nanoparticles enhanced the entry and particle retention to the reticuloendothelial system over nondecorated polymers after systemic administration into mice. These data were seen by MRI testing and validated by comparison with SMART particles and direct evaluation of tissue drug levels after nanoART. The development of alendronate (ALN)-coated magnetite thus serves as a rapid initial screen for the ability of targeting ligands to enhance nanoparticle-antiretroviral drug biodistribution, underscoring the value of decorated magnetite particles as a theranostic tool for improved drug delivery.<br />Video abstract
- Subjects :
- Male
theranostics
Pharmaceutical Science
02 engineering and technology
Mice
Drug Delivery Systems
International Journal of Nanomedicine
Drug Discovery
Tissue Distribution
Molecular Targeted Therapy
Magnetite Nanoparticles
Mononuclear Phagocyte System
Original Research
media_common
Mice, Inbred BALB C
0303 health sciences
Alendronate
Nanoart
Dextrans
General Medicine
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
3. Good health
Nanomedicine
Anti-Retroviral Agents
Drug delivery
Systemic administration
0210 nano-technology
Drug
Biodistribution
magnetite
Materials science
media_common.quotation_subject
Atazanavir Sulfate
Biophysics
Bioengineering
Nanotechnology
Biomaterials
folic acid
03 medical and health sciences
Pharmacokinetics
Animals
030304 developmental biology
Macrophages
Organic Chemistry
Reproducibility of Results
Pharmacodynamics
decorated nanoparticles
Biomedical engineering
Subjects
Details
- ISSN :
- 11782013
- Database :
- OpenAIRE
- Journal :
- International Journal of Nanomedicine
- Accession number :
- edsair.doi.dedup.....8b8dd1afe75051f7ac405142c43672a6