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Expression of Hsp72 in Lymphocytes in Patients with Febrile Convulsion
- Source :
- Kaohsiung Journal of Medical Sciences, Vol 21, Iss 3, Pp 101-107 (2005)
- Publisher :
- Elsevier. Published by Elsevier B.V.
-
Abstract
- The pathophysiology of febrile convulsion, the most common childhood neurologic disease, remains unclear. In this study, we investigated what role a heat shock protein plays in this disease. We enrolled eight boys and two girls with febrile convulsion and 10 age-matched healthy controls. We did a biosynthetic evaluation of both groups by separating lymphocytes and measuring the expression of heat shock protein 72 before and after heat shock treatment. Before the treatment, both groups were found to have small amounts of constitutive heat shock protein 72. Afterwards, its expression increased in both groups, and no statistical difference was found between the increases in the two groups. In addition, there was no obvious difference in the susceptibility to produce heat shock proteins. However, the febrile convulsion group was found to have a significant decrease in phosphorylation of heat shock protein 72. These results suggest the possible involvement of post-translational modification of heat shock proteins, most likely phosphorylation, in the pathogenesis of febrile convulsion.
- Subjects :
- Male
heat shock protein
HSP72 Heat-Shock Proteins
Seizures, Febrile
febrile convulsion
Pathogenesis
Heat shock protein
Convulsion
Immunochemistry
Medicine
Humans
Lymphocytes
Heat-Shock Proteins
Medicine(all)
lcsh:R5-920
business.industry
phosphorylation
Case-control study
Infant
General Medicine
Pathophysiology
Shock (circulatory)
Case-Control Studies
Child, Preschool
Immunology
Phosphorylation
Electrophoresis, Polyacrylamide Gel
Female
medicine.symptom
business
lcsh:Medicine (General)
Subjects
Details
- Language :
- English
- ISSN :
- 1607551X
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Kaohsiung Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....8b8c51e52e496e5e60bebef80bf8e2ae
- Full Text :
- https://doi.org/10.1016/S1607-551X(09)70285-2