Back to Search
Start Over
MRI of cortical dysplasia - correlation with pathological findings
- Source :
- Neuroradiology. 43:830-837
- Publication Year :
- 2001
- Publisher :
- Springer Science and Business Media LLC, 2001.
-
Abstract
- Cortical dysplasia (CD) is the most epileptogenic structural lesion associated with epilepsy and patients with intractable seizures caused by this condition are good surgical candidates. MRI plays an important role in detecting the abnormalities of CD. We clarified the MRI characteristics of CD by comparing imaging and histological findings in 20 patients with intractable seizures who underwent surgical resection. There were 12 males and eight females, mean age at operation was 15 years. MRI was performed at 1.5 tesla; T1-weighted, T2- and proton density-weighted spin-echo and fluid-attenuated inversion-recovery (FLAIR) images were obtained. The lesions were in the frontal lobe in nine cases, temporal in two, occipital in another two, insular in one and multilobar in six. Blurring of the grey/white matter junction was seen in all patients, and T2 prolongation in white matter and/or at the grey/white matter junction in 19. Abnormal signal intensity was more frequent in the white matter or at the grey/white matter junction than in the grey matter. FLAIR images made this abnormal high signal easier to appreciate, and we thought them very useful in this context. In areas of T2 prolongation, we saw dysplastic neurones and/or balloon cells, dysmyelination, and ectopic neuronal clustering histologically; glial proliferation played an important role in prolonging T2.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Context (language use)
Grey matter
Fluid-attenuated inversion recovery
White matter
Epilepsy
medicine
Humans
Radiology, Nuclear Medicine and imaging
Child
Cerebral Cortex
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Cortical dysplasia
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Dysplasia
Child, Preschool
Female
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 14321920 and 00283940
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Neuroradiology
- Accession number :
- edsair.doi.dedup.....8b76eddc2755e92ecc3fa65f9a6e2813