Molecular cloning of a cDNA encoding human antihaemophilic factor

Authors :: John J. Toole
John L. Knopf
John M. Wozney
Lisa A. Sultzman
Janet L. Buecker
Debra D. Pittman
Randal J. Kaufman
Eugene Brown
Charles Shoemaker
Elizabeth C. Orr
Godfrey W. Amphlett
W. Barry Foster
Mary Lou Coe
Gaylord J. Knutson
David N. Fass
Rodney M. Hewick
Source :: Nature. 312:342-347
Publication Year :: 1984
Publisher :: Springer Science and Business Media LLC, 1984.
Abstract: A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.