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A smart approach for delivery of aripiprazole via oro-soft palatal mucosal route for improved therapeutic efficacy
- Source :
- Brazilian Journal of Pharmaceutical Sciences, Vol 54, Iss 3 (2018), Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 3 (2018); e17382, Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 3 (2018); e17382, Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 3 (2018); e17382, Brazilian Journal of Pharmaceutical Sciences, Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2018
- Publisher :
- Universidade de São Paulo, 2018.
-
Abstract
- Effective management of schizophrenia, acute mania, mixed episodes associated with bipolar disorders, and depression can be managed with aripiprazole moiety. In the present research work an attempt was made to minimize the dose related side effects thus improving the quality life of the patients. A novel biopolymer was isolated from the fruits of Trachyspermum ammi. Ten optimized nanosized aripiprazole loaded formulations were prepared in 1-5% concentration of biopolymer (FA1-FA5) and sodium CMC (FM1-FM5) by solvent casting technique. The formulated flexy films were evaluated for thickness, folding endurance, weight uniformity, surface pH, mucoadhesivity, In-vitro drug release studies, In-vivo pharmacodynamic study and stability studies. The isolated biopolymer showed inbuilt fimability and mucoadhesivity and consists of carbonyl, hydroxyl and thiocarbonyl functional groups. All formulations showed folding endurance from 153 to 170, mucoadhesion time in the range of 24-48hrs., and in-vitro drug release was performed using dynamic Franz Diffusion cell and analyzed using BIT-SOFTWARE. The experimental animals showed improved activity score on actophotometer. The formulated nanosized aripiprazole loaded bio-flexy films showed pharmacotherapeutic response. Conclusion can be drawn that optimized formulation showed effective Pharmacodynamic activity and can be used as for improving therapeutic efficacy of aripiprazole through this platform.
- Subjects :
- Franz diffusion cell
Aripiprazole/therapeutic efficacy
lcsh:RS1-441
02 engineering and technology
engineering.material
010402 general chemistry
01 natural sciences
lcsh:Pharmacy and materia medica
Mucoadhesion
medicine
Chemistry
Effective management
021001 nanoscience & nanotechnology
Folding endurance
0104 chemical sciences
Pharmacodynamic Study
Pharmacodynamics
engineering
Schizophrenia
Aripiprazole
Biopolymer
Nanosized
Mucoadhesive
Oro-soft palatal mucosal route
0210 nano-technology
Biomedical engineering
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 21759790 and 19848250
- Volume :
- 54
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Brazilian Journal of Pharmaceutical Sciences
- Accession number :
- edsair.doi.dedup.....8b4779a9257446a3c03c9f8b8858439d