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The Impact of Childhood Adversity on Cognitive Development in Schizophrenia
- Source :
- Schizophr Bull
- Publication Year :
- 2019
-
Abstract
- Childhood adversity, such as physical, sexual, and verbal abuse, as well as neglect and family conflict, is a risk factor for schizophrenia. Such adversity can lead to disruptions of cognitive function during development, undermining intellectual capabilities and academic achievement. Schizophrenia is a neurodevelopmental disorder that is associated with cognitive impairments that may become evident during childhood. The Australian Schizophrenia Research Bank database comprises a large community cohort (N = 1169) in which we previously identified 3 distinct cognitive groups among people with schizophrenia: (1) Compromised, current, and estimated premorbid cognitive impairment; (2) Deteriorated, substantial decline from estimated premorbid function; and (3) Preserved, performing in the normal cognitive range without decline. The compromised group displayed the worst functional and symptom outcomes. Here, we extend our previous work by assessing the relationship among these categories of cognitive abilities and reported childhood adversity in 836 patients and healthy controls. Exploratory factor analysis of the Childhood Adversity Questionnaire revealed 3 factors (lack of parental involvement; overt abuse; family breakdown and hardship). People with schizophrenia reported significantly more childhood adversity than healthy controls on all items and factors. People with schizophrenia in the compromised group reported significantly more lack of parental involvement and family breakdown and hardship and lower socioeconomic status than those in the deteriorated group. The cognitive groups were not related to family history of psychosis. These findings identify specific social and family factors that impact cognition, highlighting the important role of these factors in the development of cognitive and functional abilities in schizophrenia.
- Subjects :
- Adult
Male
Psychosis
media_common.quotation_subject
Human Development
Verbal abuse
behavioral disciplines and activities
Neglect
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Adverse Childhood Experiences
mental disorders
medicine
Cognitive development
Humans
Cognitive Dysfunction
Functional ability
Family history
media_common
Australia
Cognition
Middle Aged
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Adult Survivors of Child Adverse Events
Psychotic Disorders
Schizophrenia
Female
Psychology
030217 neurology & neurosurgery
Clinical psychology
Regular Articles
Subjects
Details
- ISSN :
- 17451701
- Volume :
- 46
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Schizophrenia bulletin
- Accession number :
- edsair.doi.dedup.....8b434861c53efbba9ea1cc90d3bdec69