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An integrative look at SARS‑CoV‑2 (Review)
An integrative look at SARS‑CoV‑2 (Review)
- Source :
- International Journal of Molecular Medicine, e_Buah Biblioteca Digital Universidad de Alcalá, instname
- Publication Year :
- 2020
- Publisher :
- Spandidos Publications, 2020.
-
Abstract
- SARS‑CoV‑2 is a newly discovered member of the betacoronaviruses and the etiological agent of the disease COVID‑19. SARS‑CoV‑2 is responsible for the worldwide pandemic which has been taking place in 2020, and is causing a markedly higher number of infections and deaths compared to previous coronaviruses, such as SARS‑CoV or MERS‑CoV. Based on updated scientific literature, the present review compiles the most relevant knowledge of SARS‑CoV‑2, COVID‑19 and the clinical and typical responses that patients have exhibited against this virus, discussing current and future therapies, and proposing strategies with which to combat the disease and prevent a further global threat. The aggressiveness of SARS‑CoV‑2 arises from its capacity to infect, and spread easily and rapidly through its tight interaction with the human angiotensin‑converting enzyme 2 (ACE‑2) receptor. While not all patients respond in a similar manner and may even be asymptomatic, a wide range of manifestations associated with COVID‑19 have been described, particularly in vulnerable population groups, such as the elderly or individuals with other underlying conditions. The proper function of the immune system plays a key role in an individual's favorable response to SARS‑CoV‑2 infection. A hyperactivated response, on the contrary, could account for the more severe cases of COVID‑19, and this may finally lead to respiratory insufficiency and other complications, such as thrombotic or thromboembolic events. The development of novel therapies and vaccines designed to control and regulate a proper immune system response will be key to clinical management, prevention measures and effective population screening to attenuate the transmission of this novel RNA virus.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Medicina
coronavirus
Disease
medicine.disease_cause
Asymptomatic
immune response
targeted drug delivery
Virus
03 medical and health sciences
0302 clinical medicine
Immune system
vaccine
Pandemic
Genetics
medicine
Humans
Intensive care medicine
Pandemics
Coronavirus
therapy
SARS-CoV-2
Transmission (medicine)
business.industry
prevention and clinical management
COVID-19
Química
Articles
General Medicine
Chemistry
030104 developmental biology
030220 oncology & carcinogenesis
Etiology
Medicine
medicine.symptom
business
Subjects
Details
- ISSN :
- 1791244X and 11073756
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Medicine
- Accession number :
- edsair.doi.dedup.....8b3533cf8673050af8bf05589b5735dc
- Full Text :
- https://doi.org/10.3892/ijmm.2020.4828