Delta-Di-carboxybutyl phosphoramidate of 2'-deoxycytidine-5'-monophosphate as substrate for DNA-polymerization by HIV-1 reverse transcriptase

Authors :: Piet Herdewijn
Jean-Jacques Vasseur
François Morvan
Ivan Zlatev
Anne Giraut
Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM)
Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)
Source :: Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry, Elsevier, 2009, 17, pp.7008-7014. ⟨10.1016/j.bmc.2009.08.001⟩
Publication Year :: 2009
Publisher :: HAL CCSD, 2009.
Abstract: The replacement of the pyrophosphate moiety of 2′-deoxynucleoside triphosphates by non natural δ-dicarboxylic butyl amino acid allows incorporation of natural 2′-deoxycytidine into DNA using HIV-1 reverse transcriptase (RT) as enzyme. In contrast, the 3′-deoxycytidine analogue was not a substrate of the HIV-1 RT.

Language :: English
ISSN :: 09680896 and 14643391
Database :: OpenAIRE
Journal :: Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry, Elsevier, 2009, 17, pp.7008-7014. ⟨10.1016/j.bmc.2009.08.001⟩
Accession number :: edsair.doi.dedup.....8b2c2b4f488db83b47601cc1ee3c1dec

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