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Delta-Di-carboxybutyl phosphoramidate of 2'-deoxycytidine-5'-monophosphate as substrate for DNA-polymerization by HIV-1 reverse transcriptase
- Source :
- Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry, Elsevier, 2009, 17, pp.7008-7014. ⟨10.1016/j.bmc.2009.08.001⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- The replacement of the pyrophosphate moiety of 2′-deoxynucleoside triphosphates by non natural δ-dicarboxylic butyl amino acid allows incorporation of natural 2′-deoxycytidine into DNA using HIV-1 reverse transcriptase (RT) as enzyme. In contrast, the 3′-deoxycytidine analogue was not a substrate of the HIV-1 RT.
- Subjects :
- DNA Replication
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
010402 general chemistry
01 natural sciences
Biochemistry
Pyrophosphate
Substrate Specificity
chemistry.chemical_compound
Drug Discovery
Phosphoric Acids
Nucleotide
Molecular Biology
Polymerase
ComputingMilieux_MISCELLANEOUS
chemistry.chemical_classification
biology
010405 organic chemistry
[CHIM.ORGA]Chemical Sciences/Organic chemistry
RNA-Directed DNA Polymerase
Organic Chemistry
Phosphoramidate
Deoxycytidine Monophosphate
Amides
HIV Reverse Transcriptase
Reverse transcriptase
Amino Acids, Dicarboxylic
0104 chemical sciences
Enzyme
chemistry
biology.protein
Molecular Medicine
DNA
Subjects
Details
- Language :
- English
- ISSN :
- 09680896 and 14643391
- Database :
- OpenAIRE
- Journal :
- Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry, Elsevier, 2009, 17, pp.7008-7014. ⟨10.1016/j.bmc.2009.08.001⟩
- Accession number :
- edsair.doi.dedup.....8b2c2b4f488db83b47601cc1ee3c1dec