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Serological evidence of vector and parasite exposure in Southern Ghana: the dynamics of malaria transmission intensity
- Source :
- Badu, K; Gyan, B; Appawu, M; Mensah, D; Dodoo, D; Yan, G; et al.(2015). Serological evidence of vector and parasite exposure in Southern Ghana: The dynamics of malaria transmission intensity. Parasites and Vectors. doi: 10.1186/s13071-015-0861-y. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3kp735t4, Parasites & vectors, vol 8, iss 1, Parasites & Vectors, Badu, K; Gyan, B; Appawu, M; Mensah, D; Dodoo, D; Yan, G; et al.(2015). Serological evidence of vector and parasite exposure in Southern Ghana: the dynamics of malaria transmission intensity. Parasites & vectors, 8, 251. doi: 10.1186/s13071-015-0861-y. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7sf1t7mh
- Publisher :
- Springer Nature
-
Abstract
- © 2015 Badu et al.; licensee BioMed Central. Background: Seroepidemiology provides robust estimates for tracking malaria transmission when intensity is low and useful when there is no baseline entomological data. Serological evidence of exposure to malaria vectors and parasite contribute to our understanding of the risk of pathogen transmission, and facilitates implementation of targeted interventions. Ab to Anopheles gambiae salivary peptide (gSG6-P1) and merozoite surface protein one (MSP-119) reflect human exposure to malaria vectors and parasites. This study estimated malaria transmission dynamics using serological evidence of vector and parasite exposure in southern Ghana. Methods: Total IgG responses to both antigens in an age stratified cohort (14) were measured from South-eastern Ghana. 295 randomly selected sera were analyzed from archived samples belonging to a cohort study that were followed at 3 consecutive survey months (n = 885); February, May and August 2009. Temporal variations in seroprevalence of both antigens as well as differences between the age-stratified cohorts were determined by χ 2 test with p < 0.05 statistically significant. Non-parametric repeated ANOVA - Friedman's test was used to test differences in antibody levels. Seroprevalence data were fitted to reversible catalytic model to estimate sero-conversion rates. Results: Whereas parasite prevalence was generally low 2.4%, 2.7% and 2.4% with no apparent trends with season, seroprevalence to both gSG6-P1 and MSP119 were high (59%, 50.9%, 52.2%) and 57.6%, 52.3% and 43.6% in respective order from Feb. to August. Repeated measures ANOVA showed differences in median antibody levels across surveys with specific significant differences between February and May but not August by post hoc Dunn's multiple comparison tests for gSG6-P1. For MSP119, no differences were observed in antibody levels between February and May but a significant decline was observed from May to August. Seroconversion rates for gSG6-P1 increased by 1.5 folds from February to August and 3 folds for MSP119. Conclusion: Data suggests exposure to infectious bites may be declining whereas mosquito bites remains high. Sustained malaria control efforts and surveillance are needed to drive malaria further down and to prevent catastrophic rebound. Operational factors for scaling up have been discussed.
- Subjects :
- Veterinary medicine
Malaria exposure
Anopheles gambiae
Seroprevalence
Mycology & Parasitology
Ghana
Salivary peptide
Seroepidemiologic Studies
2.2 Factors relating to the physical environment
Malaria, Falciparum
Aetiology
Child
Merozoite Surface Protein 1
biology
Merozoite surface protein
Infectious Diseases
Medical Microbiology
Child, Preschool
Cohort
Public Health and Health Services
Infection
Cohort study
Biotechnology
Falciparum
Adult
Adolescent
Insect bites and stings
Young Adult
Rare Diseases
Tropical Medicine
Anopheles
parasitic diseases
medicine
Animals
Humans
Seroconversion
Salivary Proteins and Peptides
Preschool
Parasite prevalence
Research
Insect Bites and Stings
biology.organism_classification
medicine.disease
Malaria
Vector-Borne Diseases
Good Health and Well Being
Vector (epidemiology)
Immunoglobulin G
Immunology
Parasitology
Seroconversion rate
Subjects
Details
- Language :
- English
- ISSN :
- 17563305
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Parasites & Vectors
- Accession number :
- edsair.doi.dedup.....8b2a357aa7609e94ba5ba9f55c4805df
- Full Text :
- https://doi.org/10.1186/s13071-015-0861-y