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Fractionated Laser Resurfacing Corrects the Inappropriate UVB Response in Geriatric Skin
- Source :
- The Journal of investigative dermatology
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Non-melanoma skin cancer is a disease primarily afflicting geriatric patients as evidenced by the fact that 80% of all non-melanoma skin cancers are diagnosed in patients over the age of 60 years. As such, geriatric skin responds to cancer-inducing UVB irradiation in a manner that allows the establishment of tumor cells. Currently, the only effective treatment for non-melanoma skin cancer is the removal of the tumors after they appear, indicating the need for a more cost-effective prophylactic therapy. Geriatric volunteers were treated with fractionated laser resurfacing therapy on either sun-protected (upper buttocks) or chronically sun-exposed (dorsal forearm) skin. Fractionated laser resurfacing therapy was demonstrated to decrease the occurrence of senescent fibroblasts in geriatric dermis, increase the dermal expression of insulin-like growth factor-1, and correct the inappropriate UVB response observed in untreated geriatric skin. These responses to fractionated laser resurfacing were equal to the effects seen previously using the more aggressive wounding following dermabrasion. Furthermore, fractionated laser resurfacing was equally effective in both sun-protected and sun-exposed skin. The ability of fractionated laser resurfacing treatment to protect against the occurrence of UVB-damaged proliferating keratinocytes indicates the potential of fractionated laser resurfacing to reduce or prevent aging-associated non-melanoma skin cancer.
- Subjects :
- Keratinocytes
medicine.medical_specialty
Skin Neoplasms
Ultraviolet Rays
medicine.medical_treatment
Dermatology
Biochemistry
Article
Collagen Type I
Skin Aging
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Dermis
Forearm
medicine
Carcinoma
Humans
Insulin-Like Growth Factor I
Buttocks
Molecular Biology
Cellular Senescence
Aged
Cell Proliferation
integumentary system
business.industry
Dermabrasion
Cell Biology
medicine.disease
3. Good health
Collagen Type I, alpha 1 Chain
medicine.anatomical_structure
Carcinoma, Basal Cell
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Sunlight
Laser Therapy
Skin cancer
business
Cell aging
Subjects
Details
- ISSN :
- 0022202X
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology
- Accession number :
- edsair.doi.dedup.....8b20c51e154b07eb0d5c056f3cf80743