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Consensus Recommendations from the Spanish Germ Cell Cancer Group on the Use of High-dose Chemotherapy in Germ Cell Cancer
- Source :
- European Urology Focus. 3:280-286
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background High-dose chemotherapy (HDCT) has been studied in several clinical scenarios in advanced germ cell cancer (GCC). Objective To establish a clinical practice guideline for HDCT use in the treatment of GCC patients. Design, setting, and participants An expert panel reviewed information available from the literature. The panel addressed relevant issues concerning and related to HDCT. The guideline was externally reviewed by two international experts. Results and limitations The efficacy of HDCT has been demonstrated in selected GCC patients. The most conclusive evidence comes from retrospective analyses that need to be interpreted with caution. HDCT can cure a significant proportion of heavily treated GCC patients. When indicated, sequential HDCT with regimens containing carboplatin and etoposide, as well as peripheral stem-cell support, is recommended. There is no conclusive evidence to recommend HDCT as first-line therapy. According to a multinational retrospective pooled analysis, HDCT might be superior to conventional CT as first salvage treatment in selected patients. There is an urgent need for prospective clinical trials addressing the value of HDCT in GCC patients who experience failure on first-line cisplatin-based CT. In patients who progress on conventional-dose salvage CT, HDCT should be considered. Treatment of these patients at experienced centers is strongly recommended. Conclusions It has been demonstrated that HDCT cures selected GCC patients who experience disease progression on conventional rescue regimens. The panel recommends the inclusion of GCC patients in randomized clinical trials including HDCT. Patient summary This consensus establishes clinical practice guidelines for the use and study of high-dose chemotherapy in patients with germ cell cancer.
- Subjects :
- Male
0301 basic medicine
Oncology
medicine.medical_specialty
Consensus
Urology
medicine.medical_treatment
Salvage therapy
law.invention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Testicular Neoplasms
Randomized controlled trial
law
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Etoposide
Salvage Therapy
Chemotherapy
business.industry
Guideline
Neoplasms, Germ Cell and Embryonal
Carboplatin
Surgery
Clinical trial
030104 developmental biology
Germ cell cancer
chemistry
Spain
030220 oncology & carcinogenesis
business
medicine.drug
Subjects
Details
- ISSN :
- 24054569
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- European Urology Focus
- Accession number :
- edsair.doi.dedup.....8b194ae6299305eaa259aa7e30a0313f