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A Comparative Study of Short Term versus Long Term Administration of Prophylactic Antibiotics in Elective Lower Segment Caesarean Section

A Comparative Study of Short Term versus Long Term Administration of Prophylactic Antibiotics in Elective Lower Segment Caesarean Section

Authors :
Alka Murlidhar Patankar
Prashaant Arun Uikey
Aashima Mittar Sen Garg
Megha Pandurang Tajne
Swati Patel
Source :
Journal of Evidence Based Medicine and Healthcare, Vol 7, Iss 36, Pp 1933-1937 (2020)
Publication Year :
2020
Publisher :
Level Up Business Center, 2020.

Abstract

BACKGROUND There is an increasing incidence of caesarean section around the world. As caesarean section is associated with infectious complications, frequent and inappropriate use of all newly discovered antimicrobial drugs has led to the development of altered mechanisms and treatment failure or ineffective management of such patients which increase the rate of morbidity and mortality in mothers. Many guidelines and studies recommend single dose antibiotic prophylaxis for women undergoing elective or non-elective caesarean section. The aim of this study was to assess the effectiveness of ceftriaxone as prophylactic antibiotic in elective caesarean section patients. METHODS This study was carried out in Indira Gandhi Government Medical College and Hospital, Nagpur from 2017 to 2019. Approval from Institutional Ethics committee was taken prior to commencement of the study. Two hundred patients were included in the study from wards who fulfilled the inclusion criteria. They were divided into two groups, group 1 had hundred patients who received inj. Ceftriaxone as single dose prophylaxis after cord clamping. Group 2 of hundred patients received combination of inj. cefotaxime, metronidazole and gentamicin, which was administered for 2 days IV followed by oral Augmentin for 5 days Postoperatively. The efficacy was measured in terms of febrile morbidity, wound infection, duration of hospital stay, and cost of antibiotic. RESULTS Febrile morbidity was significantly less in group 1 compared to group 2. 3% from group 1 and 16% from group 2 had wound discharge and therefore, the difference was statistically significant (p=0.003). 2% from group 1 and 9% from group 2 presented with wound dehiscence (p=0.027). 74% from group 1 had a shorter hospital stay of 7 days (p=

Details

ISSN :
23492570 and 23492562
Volume :
7
Database :
OpenAIRE
Journal :
Journal of Evidence Based Medicine and Healthcare
Accession number :
edsair.doi.dedup.....8b18b80fc6c794324cb92cfeb78cfe3f
Full Text :
https://doi.org/10.18410/jebmh/2020/402