The expression and significance of Dickkopf-1 in epithelial ovarian carcinoma

The aim of this study was to investigate the presence and prognostic value of Dickkopf-1 (DKK1) in epithelial ovarian carcinoma. The expression of DKK1 was determined in 56 epithelial ovarian carcinoma tissues, 35 benign ovarian cystadenoma tissues, and 12 normal ovarian tissues by quantitative real-time PCR and immunohistochemistry. The DKK1 mRNA level in the carcinoma tissues was upregulated (5.5±2.7-fold increase) compared with that in the normal tissues (p