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Dynamic Changes in Serum IGF-I and Growth During Infancy: Associations to Body Fat, Target Height, and PAPPA2 Genotype
- Source :
- The Journal of clinical endocrinology and metabolism. 107(1)
- Publication Year :
- 2021
-
Abstract
- Context IGF-I is important for postnatal growth and may be of diagnostic value in infants suspected of pituitary disease; however, little is known about the impact of IGF-I and its determinants on infant growth. Importantly, detailed reference ranges for IGF-I and IGF binding protein-3 (IGFBP-3) concentrations during infancy are lacking. Objective To evaluate the rapid changes in weight and length as well as their determinants in healthy infants, and to establish age- and sex-specific reference curves for IGF-I and IGFBP-3 in children aged 0 to 1 years. Design Prospective longitudinal study. Setting Cohort study. Participants A total of 233 healthy children (114 girls) with repeated blood samples during the first year of life. Main Outcome Measure(s) Serum concentrations of IGF-I and IGFBP-3, length velocity, weight velocity, and PAPPA2 (rs1325598) genotype. Results Individual trajectories of length and weight velocities were sex specific. We provide detailed reference curves based on longitudinal data for IGF-I and IGFBP-3 during infancy. In both girls and boys, IGF-I decreased during infancy, whereas IGFBP-3 remained stable. IGF-I and IGFBP-3, but not PAPPA2 genotype, were positively associated with weight gain, but not with longitudinal growth. When stratified by sex, the association between weight gain and IGF-I only remained significant in girls. Conclusions Interestingly, we found a significant association between IGF-I and infant weight gain in girls, but not with longitudinal growth in the first year of life. Our findings highlight the role of IGF-I as an important anabolic hormone that is not limited to linear growth.
- Subjects :
- Male
Longitudinal study
medicine.medical_specialty
Pituitary disease
Anabolism
Genotyping Techniques
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Context (language use)
Weight Gain
Biochemistry
Polymorphism, Single Nucleotide
Endocrinology
Child Development
Sex Factors
Reference Values
Internal medicine
Genotype
medicine
Humans
Pregnancy-Associated Plasma Protein-A
Longitudinal Studies
Prospective Studies
Insulin-Like Growth Factor I
business.industry
Biochemistry (medical)
Body Weight
Infant, Newborn
Infant
medicine.disease
Body Height
Healthy Volunteers
Insulin-Like Growth Factor Binding Protein 3
Female
medicine.symptom
business
Weight gain
Cohort study
Hormone
Subjects
Details
- ISSN :
- 19457197
- Volume :
- 107
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....8b14188365f8c9445a65aee5458681c9