High-resolution frequency tuning but not temporal coding in the human cochlea

Frequency tuning and phase-locking are two fundamental properties generated in the cochlea, enabling but also limiting the coding of sounds by the auditory nerve (AN). In humans, these limits are unknown, but high resolution has been postulated for both properties. Electrophysiological recordings from the AN of normal-hearing volunteers indicate that human frequency tuning, but not phase-locking, exceeds the resolution observed in animal models.
Author summary The coding of sounds by the cochlea depends on two primary properties: frequency selectivity, which refers to the ability to separate sounds into their different frequency components, and phase-locking, which refers to the neural coding of the temporal waveform of these components. These properties have been well characterized in animals using neurophysiological recordings from single neurons of the auditory nerve (AN), but this approach is not feasible in humans. As a result, there is considerable controversy as to how these two properties may differ between humans and the small animals typically used in neurophysiological studies. It has been proposed that humans excel both in frequency selectivity and in the range of frequencies over which they have phase-locking. We developed a technique to quantify these properties using mass potentials from the AN, recorded via the middle ear in human volunteers with normal hearing. We find that humans have unusually sharp frequency tuning but that the upper frequency limit of phase-locking is at best similar to—and more likely lower than—that of the nonhuman animals conventionally used in experiments.