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Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish

Authors :
Kaj Kamstra
Mohammed Z. Rizwan
David R. Grattan
Julia A. Horsfield
Alexander Tups
Source :
The FASEB Journal. 36
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

Leptin is best known for its role in adipostasis, but it also regulates blood glucose levels. The molecular mechanism by which leptin controls glucose homeostasis remains largely unknown. Here, we use a zebrafish model to show that Wnt signaling mediates the glucoregulatory effects of leptin. Under normal feeding conditions, leptin regulates glucose homeostasis but not adipostasis in zebrafish. In times of nutrient excess, however, we found that leptin also regulates body weight and size. Using a Wnt signaling reporter fish, we show that leptin activates the canonical Wnt pathway in vivo. Utilizing two paradigms for hyperglycemia, it is revealed that leptin regulates glucose homeostasis via the Wnt pathway, as pharmacological inhibition of this pathway impairs the glucoregulatory actions of leptin. Our results may shed new light on the evolution of the physiological function of leptin.

Details

ISSN :
15306860 and 08926638
Volume :
36
Database :
OpenAIRE
Journal :
The FASEB Journal
Accession number :
edsair.doi.dedup.....8b0cf9d0674a6e88ed12307ad3b264eb
Full Text :
https://doi.org/10.1096/fj.202101764r