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Discoidin domain receptors (DDRs): Potential implications in periodontitis
- Source :
- Journal of Cellular Physiology. 237:189-198
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Periodontitis is a chronic inflammatory disease leading to the destruction of periodontal tissues associated with high prevalence and significant economic burden. As special collagen-binding tyrosine kinase receptors, the discoidin domain receptors (DDRs) can control cell migration, adhesion, proliferation, and extracellular matrix remodeling. DDRs are constitutively expressed and widely distributed in periodontal tissues which are rich in collagen. Ddr1/2 knockout mice showed significant periodontal defects including connective tissue destruction, alveolar bone loss, and even tooth loss. It has been demonstrated that bone homeostasis, inflammation, matrix metalloproteinases, and autophagy are crucial characteristics involved in the pathogenesis of periodontitis. Of note, DDRs have been reported to participate in the above pathophysiological processes, implicating the potential roles of DDRs in periodontitis. In this review article, we aim to illustrate the possible roles of DDRs in periodontitis in an attempt to explore their potential value as therapeutic targets for periodontitis.
- Subjects :
- Physiology
Clinical Biochemistry
Inflammation
Matrix metalloproteinase
Receptor tyrosine kinase
Extracellular matrix
Mice
Animals
Medicine
Periodontitis
Receptor
Discoidin Domain Receptors
DDR1
biology
business.industry
Receptor Protein-Tyrosine Kinases
Cell Biology
medicine.disease
Receptors, Mitogen
biology.protein
Cancer research
Collagen
medicine.symptom
business
Discoidin domain
Subjects
Details
- ISSN :
- 10974652 and 00219541
- Volume :
- 237
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Physiology
- Accession number :
- edsair.doi.dedup.....8b0c9d0de1c6133befc304abea63af42