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Impaired Gremlin 1 (GREM1) expression in cumulus cells in young women with diminished ovarian reserve (DOR)
- Publication Year :
- 2011
- Publisher :
- Springer US, 2011.
-
Abstract
- A symbiotic relationship between ovarian granulosa cells (GC) and the developing oocyte is critical. Genetic modulations in GC's can lead to reproductive insufficiency, highlighting the role of GC's in reproductive competence. Utilizing gene expression analyses in cumulus GC's, we attempt to enhance our understanding of mechanisms that may contribute to poor reproductive capacity in young women with diminished ovarian reserve (DOR).We measured gremlin 1 (GREM1) gene expression in GC's from infertile women38 years undergoing in vitro fertilization in the context of DOR.GREM1, a member of the differential screening-selected gene aberrative in neuroblastoma (DAN) family of genes known for its highly regulated expression pattern during folliculogenesis and a downstream effecter of oocyte-derived growth and differentiation factor 9, was down-regulated 3-fold (-3.08) in women with DOR versus control; down-regulation was confirmed by qRT-PCR (-4.02).This is the first demonstration linking differential expression of Gremlin with etiology of infertility in women.
- Subjects :
- Infertility
endocrine system
medicine.medical_specialty
Reproductive medicine
Down-Regulation
Growth Differentiation Factor 9
Fertilization in Vitro
Growth differentiation factor-9
Biology
Oogenesis
Downregulation and upregulation
Pregnancy
Internal medicine
Gene expression
Genetics
medicine
Humans
Genetics (clinical)
Cumulus Cells
Female infertility
Ovary
Obstetrics and Gynecology
General Medicine
medicine.disease
Oocyte
Endocrinology
medicine.anatomical_structure
Reproductive Medicine
Oocytes
Intercellular Signaling Peptides and Proteins
Female
Gonad Physiology and Disease
Infertility, Female
Developmental Biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8b01d4baad24c7377d0daa1173c58069