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The TRIMCyp genotype in four species of macaques in China
- Source :
- Immunogenetics. 65:185-193
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression status of TRIMCyp in four species of macaques originating from China and its borderlands: pigtail macaques (Macaca nemestrina), rhesus macaques (Macaca mulatta), long-tailed macaques (Macaca fascicularis), and Tibetan macaques (Macaca thibetana). The results revealed that the frequencies of the TRIMCyp genotype were significantly different among different species and even within different populations of the same species. Interestingly, the TRIMCyp genotype was more prevalent among macaques originating from Yunnan and surrounding regions than those from other regions of China. Importantly, TRIMCyp individuals were first identified in Chinese M. mulatta originating from Yunnan, although multiple earlier studies failed to find CypA retrotransposition in this subspecies. Furthermore, TRIMe7-CypA, one of the splicing isoforms of the TRIMCyp transcript was expressed in M. nemestrina and M. mulatta but not M. fascicularis. The intra- and interspecies polymorphisms in the deduced TRIMCyp amino acid sequences of these macaques were also analyzed. Taken together, the data in this study provide important information about the genomic background of TRIMCyp among major species of Chinese macaques.
- Subjects :
- China
Old World
Genotype
Retroelements
Ubiquitin-Protein Ligases
animal diseases
Pseudogene
Molecular Sequence Data
Immunology
Mutant Chimeric Proteins
HIV Infections
Retrotransposon
Cypa
Subspecies
Species Specificity
Genetics
Animals
Protein Isoforms
Frameshift Mutation
Disease Resistance
Polymorphism, Genetic
Base Sequence
biology
Macaca nemestrina
Proteins
virus diseases
Pigtail macaque
biology.organism_classification
Macaca mulatta
Macaca fascicularis
HIV-1
Macaca
Carrier Proteins
Animal Distribution
Pseudogenes
Subjects
Details
- ISSN :
- 14321211 and 00937711
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Immunogenetics
- Accession number :
- edsair.doi.dedup.....8ae95bbe08eb354ee22ec11802b07c38