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Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021), Scientific Reports, Scientific reports, vol 11, iss 1
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Growing evidence indicates that thirdhand smoke (THS) exposure induces many adverse health effects. However, it is unclear how THS exposure affects behavior and how host genetic background modulates phenotypic changes. Here we used the Collaborative Cross (CC) mouse population-based model to assess behavioral alterations immediately after THS exposure from 4 to 9 weeks of age. We first measured anxiety-like behavior in six strains using light/dark box combined with a custom multivariate mouse tracking system. We developed an anxiety risk scoring system based on anxiety-related traits and then evaluated the THS impact on them. THS exposure significantly decreased anxiety risk in CC019 (P = 0.002) and CC051 (P = 0.009), but increased anxiety risk in CC036 (P
- Subjects :
- 0301 basic medicine
Collaborative Cross Mice
Male
Scoring system
Science
Population
Physiology
Anxiety
Article
03 medical and health sciences
Third-hand smoke
0302 clinical medicine
Risk Factors
Memory
Behavioral and Social Science
Genetic variation
Genetics
2.2 Factors relating to the physical environment
Medicine
Animals
Humans
Aetiology
education
education.field_of_study
Multidisciplinary
business.industry
Prevention
Phenotype
Mental Health
030104 developmental biology
Risk factors
Cohort
Female
Tobacco Smoke Pollution
Passive avoidance
medicine.symptom
business
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....8ae665f45f57da6f64f0056eba2174ef