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5β,19-Epoxycucurbitane Triterpenoids from Momordica charantia and Their Anti-Inflammatory and Cytotoxic Activity

Authors :
Li-Jie Zhang
Ping-Chun Hsiao
Chia-Ching Liaw
Feng-Lin Hsu
Hui-Chi Huang
Syh-Yuan Hwang
Yao-Haur Kuo
Zhi-Hu Lin
Source :
Planta Medica. 81:62-70
Publication Year :
2014
Publisher :
Georg Thieme Verlag KG, 2014.

Abstract

Five new 5β,19-epoxycucurbitane triterpenoids, taikugausins A-E (1-5), together with 5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol (6), have been isolated and characterized from the 70 % EtOH extract of the fresh fruits of Momordica charantia. The chemical structures of compounds 1-6 were elucidated on the basis of extensive spectroscopic analyses, especially 2D NMR (HMQC, HMBC, and NOESY) experiments and HRESIMS data. The relationship between NMR chemical shifts and the configuration of C-19 with an OMe group in 5β,19-epoxycucurbitane are described. Among them, compounds 3 and 4 exhibited remarkable anti-inflammatory activities by the inhibition of nitric oxide production at the concentration of 10 µg/mL. In addition, 3 and 4 also showed moderate cytotoxicity against WiDr, Hep G2, MCF-7, and HEp-2 human tumor cell lines.

Details

ISSN :
14390221 and 00320943
Volume :
81
Database :
OpenAIRE
Journal :
Planta Medica
Accession number :
edsair.doi.dedup.....8ae425b283456a130f21f665c45c5eb6
Full Text :
https://doi.org/10.1055/s-0034-1383307