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Relationship between Adrenomedullin and Vasopressin-Aquaporin System under General Anesthesia
- Source :
- Hormone Research in Paediatrics. 59:30-34
- Publication Year :
- 2003
- Publisher :
- S. Karger AG, 2003.
-
Abstract
- Aim: The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated. Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined. Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level. Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.
- Subjects :
- Adult
Male
Vasopressin
medicine.medical_specialty
Time Factors
Endocrinology, Diabetes and Metabolism
Aquaporin
Anesthesia, General
Aquaporins
Adrenomedullin
Endocrinology
Atrial natriuretic peptide
Internal medicine
medicine
Humans
skin and connective tissue diseases
Aged
Body fluid
Aquaporin 2
business.industry
Middle Aged
Aquaporin 6
Arginine Vasopressin
Plasma osmolality
Creatinine
Anesthesia
Pediatrics, Perinatology and Child Health
Time course
Female
sense organs
Peptides
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 16632826 and 16632818
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Hormone Research in Paediatrics
- Accession number :
- edsair.doi.dedup.....8ade7c9af63ac3e024fe30ddfdb51c22