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Inflammasome-mediated innate immunity in Alzheimer's disease
- Source :
- The FASEB journal 33(12), 13075-13084 (2019). doi:10.1096/fj.201900439
- Publication Year :
- 2019
-
Abstract
- Historically neurodegenerative diseases, Alzheimer's disease (AD) in particular, have been viewed to be primarily caused and driven by neuronal mechanisms. Very recently, due to experimental, genetic, and epidemiologic evidence, immune mechanisms have entered the central stage and are now believed to contribute significantly to risk, onset, and disease progression of this class of disorders. Although immune activation of microglial cells may over time engage various signal transduction pathways, inflammasome activation, which represents a canonical and initiating pathway, seems to be one of the first responses to extracellular β-amyloid (Aβ) accumulation. Here we review the current understanding of inflammasome activation in AD.-Venegas, C., Heneka, M. T. Inflammasome-mediated innate immunity in Alzheimer's disease.
- Subjects :
- 0301 basic medicine
Damp
physiology [Immunity, Innate]
Inflammasomes
metabolism [Amyloid beta-Peptides]
Disease
metabolism [Microglia]
Biochemistry
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
ddc:570
Genetics
Medicine
Animals
Humans
Molecular Biology
Neuroinflammation
Innate immune system
Amyloid beta-Peptides
business.industry
Inflammasome
Immunity, Innate
immunology [Alzheimer Disease]
030104 developmental biology
Immunology
Microglia
business
metabolism [Inflammasomes]
metabolism [Alzheimer Disease]
030217 neurology & neurosurgery
Biotechnology
medicine.drug
Subjects
Details
- ISSN :
- 15306860
- Volume :
- 33
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES
- Accession number :
- edsair.doi.dedup.....8ace087a8a8bbfd25bb0536c1d5754c6