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Improving adherence to daily preexposure prophylaxis among MSM in Amsterdam by providing feedback via a mobile application
- Source :
- AIDS, 35(11), 1823-1834. Lippincott Williams & Wilkins, AIDS (London, England), 35(11), 1823-1834. Lippincott Williams and Wilkins
- Publication Year :
- 2021
-
Abstract
- Objective: Improving adherence to preexposure prophylaxis (PrEP) by providing automated feedback on self-reported PrEP use via a mobile application (app).Design: Randomized clinical trial among MSM participating in the Amsterdam PrEP demonstration project (AMPrEP).Methods: Eligible participants were randomized 1 : 1 to the control or intervention app. Both allowed daily reporting of sexual behaviour and medication intake; the intervention app also provided visual feedback. Dried blood spots collected at 12 and 24 months yielded intracellular tenofovir diphosphate concentrations (TFV-DP). We assessed proportions of participants with poor (TFV-DP Results: We randomized 229 participants, 118 to the intervention and 111 to the control arm. The primary, per-protocol, analysis included 83 participants per arm. In total, 22/166 (13%) of participants adhered poorly, 144/166 (87%) good and 66/166 (40%) excellently. App feedback did not result in a lower proportion of participants with poor adherence [control: 9 of 83 (11%); intervention: 13 of 83 (16%); P = 0.36]. App feedback did result in a larger proportion of participants with excellent adherence [control: 26/83 (31%); intervention: 40/83 (48%); P = 0.026].Conclusion: In this highly adherent population, app feedback did not improve the proportion of participants with poor adherence to PrEP.
- Subjects :
- Male
medicine.medical_specialty
Tenofovir diphosphate
Anti-HIV Agents
Immunology
Population
HIV Infections
Feedback
Medication Adherence
law.invention
Sexual and Gender Minorities
Pre-exposure prophylaxis
Trial number
Primary outcome
Randomized controlled trial
law
Intervention (counseling)
medicine
Humans
Immunology and Allergy
Homosexuality, Male
education
Dried blood
education.field_of_study
business.industry
Mobile Applications
Infectious Diseases
Physical therapy
Pre-Exposure Prophylaxis
business
Subjects
Details
- Language :
- English
- ISSN :
- 02699370
- Database :
- OpenAIRE
- Journal :
- AIDS, 35(11), 1823-1834. Lippincott Williams & Wilkins, AIDS (London, England), 35(11), 1823-1834. Lippincott Williams and Wilkins
- Accession number :
- edsair.doi.dedup.....8ab77c3fd49764388632dab4db5f8802