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Urinary Excretion of 17-Hydroxy- and 17-Deoxysteroids of the Pregn-4-ene Series by the Human Newborn
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 29:1448-1455
- Publication Year :
- 1969
- Publisher :
- The Endocrine Society, 1969.
-
Abstract
- The urinary excretion of 11β, 17α-dihydroxy-3,20-diketopregn-4-ene-21-yl sulfate (cortisol sulfate), 17α-hydroxy-3,11,20-triketopregn-4-ene-21-yl sulfate (cortisone sulfate) and of 11β-hydroxy-3,20-diketopregn-4-ene-21-yl sulfate (corticosterone sulfate) by newborn infants aged 2 and 6 days was quantified by double isotope dilution derivative assays and compared to that of known metabolites of cortisol and corticosterone. In a series of 7 newborns the sum of the urinary concentrations of cortisol and coitisone sulfates on the 2nd day of life represented represented from 43 to 114% of the amount of tetrahydrocortisone glucuronide, and on the 6th day from 8 to 155%. Corticosterone sulfate was excreted in amounts consistently much higher than tetrahydrocorticosterone glucuronide. It is concluded that the presence of these sulfate esters in urine reflects the existence of yet another pathway of corticosteioid biosynthesis and/or metabolism of particular significance during the perinatal period.
- Subjects :
- medicine.medical_specialty
Hydrocortisone
Chromatography, Paper
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Glucuronates
Urine
Tritium
Biochemistry
Anhydrides
chemistry.chemical_compound
Endocrinology
Adrenal Cortex Hormones
Corticosterone
Internal medicine
medicine
Humans
Tetrahydrocortisone
Sulfate
Tetrahydrocorticosterone
Carbon Isotopes
Sulfates
Biochemistry (medical)
Infant, Newborn
Pregnanes
Cortisone
chemistry
Chromatography, Thin Layer
Glucuronide
medicine.drug
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....8aabd907a8091934012b92cc63c3d511