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Dynamics of Nampt/visfatin and high molecular weight adiponectin in response to oral glucose load in obese and lean women
- Source :
- Clinical endocrinology. 72(4)
- Publication Year :
- 2009
-
Abstract
- Summary Background High molecular weight adiponectin (HMWA) is the active circulating form of adiponectin. Nampt/visfatin is the enzyme secreted from adipocytes in an active form and is one of the putative regulators of insulin secretion. Objective To investigate the dynamics of total adiponectin (TA), HMWA and Nampt/visfatin in obese and lean women during oral glucose tolerance test (OGTT). Methods We studied normal glucose-tolerant (NGT), age-matched, 30 obese and 30 lean women. All subjects underwent a standard 75 g, 2-h OGTT, and area under the curve (AUC) during OGTT for glucose, insulin, Nampt/visfatin, TA and HMWA was calculated. Body fat mass was assessed by bioimpedance analysis. Results Obese women had significantly higher basal and AUC values for insulin and Nampt/visfatin, whereas basal and AUC-HMWA were significantly lower in this group. Alternatively, obese and lean groups had similar basal and AUC values for glucose and TA. Basal insulin levels were negatively correlated with HMWA levels, but not with basal Nampt/visfatin. AUC-insulin was correlated positively with AUC-visfatin, and negatively with AUC-HMWA. Total and truncal body fat mass showed positive correlation with basal and AUC-visfatin, and negative correlation with basal and AUC-HMWA. Conclusion In the NGT state, obese women have higher Nampt/visfatin and lower HMWA levels, both basally and in response to oral glucose challenge. The dynamics of Nampt/visfatin and HMWA during OGTT appear to be linked with insulin and adiposity. Counter-regulatory adaptations in HMWA and Nampt/visfatin might have an impact on suggested adipoinsular axis, contributing to maintenance of normal glucose tolerance.
- Subjects :
- Adult
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Blood sugar
Body Mass Index
Endocrinology
Thinness
Internal medicine
medicine
Humans
Insulin
Obesity
Nicotinamide Phosphoribosyltransferase
Glucose tolerance test
Adiponectin
medicine.diagnostic_test
business.industry
Area under the curve
nutritional and metabolic diseases
Glucose Tolerance Test
medicine.disease
Basal (medicine)
Female
business
Body mass index
Subjects
Details
- ISSN :
- 13652265
- Volume :
- 72
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical endocrinology
- Accession number :
- edsair.doi.dedup.....8aa1c53999c569cbc4050705ff96878e