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High-performance liquid chromatography of globin chains in the identification of human globin gene abnormalities
- Source :
- Biophysical chemistry. 37(1-3)
- Publication Year :
- 1990
-
Abstract
- This article summarizes experience and data obtained using a previously developed reverse-phase high-performance liquid chromatography method (J.B. Shelton, J.R. Shelton and W.A. Schroeder, J. Liq. Chromatogr. 7 (1984) 1969) in the study of a number of hemoglobinopathies in the Sardinian population. The occurrence and incidence of several abnormal hemoglobins are described, as well as aspects of the expression of abnormal gamma-globin gene arrangements and thalassemic genes.
- Subjects :
- Macromolecular Substances
Biophysics
Biology
Biochemistry
High-performance liquid chromatography
Reference Values
medicine
Humans
Globin
Globin gene
Gene
Chromatography, High Pressure Liquid
Genetics
Gene Rearrangement
Sardinian population
Organic Chemistry
Infant, Newborn
Genetic Variation
Hemoglobin A
medicine.disease
Molecular biology
Abnormal hemoglobin
Globins
Hemoglobinopathy
Genes
Mutation
Gene Arrangements
Chromosome Deletion
Subjects
Details
- ISSN :
- 03014622
- Volume :
- 37
- Issue :
- 1-3
- Database :
- OpenAIRE
- Journal :
- Biophysical chemistry
- Accession number :
- edsair.doi.dedup.....8a9fef41c5bde7b27966c822b080d28c