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The Neutrophil/Lymphocyte Ratio at Diagnosis Is Significantly Associated with Survival in Metastatic Pancreatic Cancer Patients
- Source :
- International Journal of Molecular Sciences, Vol 18, Iss 4, p 730 (2017), International Journal of Molecular Sciences, International Journal of Molecular Sciences; Volume 18; Issue 4; Pages: 730
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Different inflammation-based scores such as the neutrophil/lymphocyte ratio (NLR), the Odonera Prognostic Nutritional Index (PNI), the Glasgow Prognostic Score, the platelet/lymphocyte ratio, and the C-reactive protein/albumin ratio have been found to be significantly associated with pancreatic cancer (PDAC) prognosis. However, most studies have investigated patients undergoing surgery, and few of them have compared these scores. We aimed at evaluating the association between inflammatory-based scores and PDAC prognosis. In a single center cohort study, inflammatory-based scores were assessed at diagnosis and their prognostic relevance as well as that of clinic-pathological variables were evaluated through multiple logistic regression and survival probability analysis. In 206 patients, age, male sex, tumor size, presence of distant metastasis, access to chemotherapy, and an NLR > 5 but not other scores were associated with overall survival (OS) at multivariate analysis. Patients with an NLR < 5 had a median survival of 12 months compared to 4 months in those with an NLR > 5. In the 81 patients with distant metastasis at diagnosis, an NLR > 5 resulted in the only variable significantly associated with survival. Among patients with metastatic disease who received chemotherapy, the median survival was 3 months in patients with an NLR > 5 and 7 months in those with an NLR < 5. The NLR might drive therapeutic options in PDAC patients, especially in the setting of metastatic disease.
- Subjects :
- Oncology
Male
Pathology
Multivariate analysis
Neutrophils
Lymphocyte
medicine.medical_treatment
pancreatic cancer
Disease
Single Center
Logistic regression
chemotherapy
lcsh:Chemistry
Leukocyte Count
0302 clinical medicine
Medicine
Lymphocytes
Neoplasm Metastasis
lcsh:QH301-705.5
Spectroscopy
General Medicine
Computer Science Applications
neutrophil/lymphocyte ratio
prognosis
biomarkers
medicine.anatomical_structure
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
Cohort study
Carcinoma, Pancreatic Ductal
medicine.medical_specialty
Adenocarcinoma
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Pancreatic cancer
Internal medicine
Biomarkers, Tumor
Humans
Physical and Theoretical Chemistry
Molecular Biology
Aged
Chemotherapy
business.industry
Organic Chemistry
fungi
medicine.disease
Survival Analysis
Pancreatic Neoplasms
lcsh:Biology (General)
lcsh:QD1-999
business
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 18
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....8a989a79e0d4daceef55c368470c8d2c