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IL‐10 producing type 2 innate lymphoid cells prolong islet allograft survival
- Source :
- EMBO Molecular Medicine, Vol 12, Iss 11, Pp n/a-n/a (2020), EMBO Molecular Medicine
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Type 2 innate lymphoid cells (ILC2s) are a subset of ILCs with critical roles in immunoregulation. However, the possible role of ILC2s as immunotherapy against allograft rejection remains unclear. Here, we show that IL‐33 significantly prolonged islet allograft survival. IL‐33‐treated mice had elevated numbers of ILC2s and regulatory T cells (Tregs). Depletion of Tregs partially abolished the protective effect of IL‐33 on allograft survival, and additional ILC2 depletion in Treg‐depleted DEREG mice completely abolished the protective effects of IL‐33, indicating that ILC2s play critical roles in IL‐33‐mediated islet graft protection. Two subsets of ILC2s were identified in islet allografts of IL‐33‐treated mice: IL‐10 producing ILC2s (ILC210) and non‐IL‐10 producing ILC2s (non‐ILC 10). Intravenous transfer of ILC210 cells, but not non‐ILC 10, prolonged islet allograft survival in an IL‐10‐dependent manner. Locally transferred ILC210 cells led to long‐term islet graft survival, suggesting that ILC210 cells are required within the allograft for maximal suppressive effect and graft protection. This study has uncovered a major protective role of ILC210 in islet transplantation which could be potentiated as a therapeutic strategy.<br />This study reveals a major protective role of the IL‐33/ILC2 axis in islet transplantation that could be potentiated as a therapeutic strategy. Adoptive transfer of ex vivo expanded IL‐10‐producing ILC2s (ILC210) significantly prolonged allograft survival.
- Subjects :
- 0301 basic medicine
Medicine (General)
type 1 diabetes
medicine.medical_treatment
Immunology
innate lymphoid cells
IL‐33
QH426-470
Regenerative Medicine
T-Lymphocytes, Regulatory
Article
IL‐10
03 medical and health sciences
Mice
0302 clinical medicine
R5-920
Allograft survival
medicine
Genetics
Animals
Lymphocytes
Type 1 diabetes
geography
geography.geographical_feature_category
business.industry
islet transplantation
Innate lymphoid cell
Immunotherapy
Articles
medicine.disease
Islet
Allografts
Immunity, Innate
Interleukin-10
Interleukin 33
Transplantation
Interleukin 10
030104 developmental biology
Metabolism
surgical procedures, operative
Molecular Medicine
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 17574676 and 17574684
- Volume :
- 12
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- EMBO Molecular Medicine
- Accession number :
- edsair.doi.dedup.....8a976a976f2b5108b517a890672fa5e9