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Effects of vitamin D supplementation on the calcium-phosphate balance in renal transplant patients
- Source :
- Kidney international. 75(6)
- Publication Year :
- 2008
-
Abstract
- Low serum levels of 25-hydroxy vitamin D frequently occur after renal transplantation, but few studies have evaluated the effects of normalizing this on serum parathyroid hormone and calcium levels or urinary calcium excretion. To determine this we compared the outcomes of 94 renal transplant patients with low 25-hydroxy vitamin D and normal serum calcium levels who were either treated or not with cholecalciferol every 2 weeks for 2 months (intensive phase) followed by an every other month maintenance phase. The biological characteristics of the two equally divided patient groups did not differ before treatment. After the intensive phase, serum 25-hydroxy vitamin D levels were normalized in all but 3 patients and the serum parathyroid hormone decreased and calcium levels increased with no severe adverse effects. During the maintenance phase, the serum 25-hydroxy vitamin D level decreased but remained significantly higher than in controls. In the control group, the serum 25-hydroxy vitamin D concentration increased slightly but became normal in only three patients. Serum 25-hydroxy vitamin D levels were significantly higher and parathyroid hormone levels were lower in treated patients compared to controls one year following transplant. Hence, cholecalciferol treatment significantly increased serum 25-hydroxy vitamin D and decreased parathyroid hormone levels with no adverse effects in 25-hydroxy vitamin D-deficient renal transplant patients.
- Subjects :
- Vitamin
Adult
Male
medicine.medical_specialty
chemistry.chemical_element
Parathyroid hormone
Calcium
Phosphates
chemistry.chemical_compound
Internal medicine
Vitamin D and neurology
medicine
Homeostasis
Humans
parathyroid
Vitamin D
Kidney
Dose-Response Relationship, Drug
business.industry
Middle Aged
Kidney Transplantation
Urinary calcium
Transplantation
medicine.anatomical_structure
Endocrinology
chemistry
Nephrology
Parathyroid Hormone
Kidney Failure, Chronic
Female
Cholecalciferol
business
Subjects
Details
- ISSN :
- 15231755
- Volume :
- 75
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Kidney international
- Accession number :
- edsair.doi.dedup.....8a8edf4cfce932bb49a8d32a8d897f82