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Frequency of the carrier state for X-linked chronic granulomatous disease among females with lupus erythematosus
- Source :
- Clinical Genetics. 10:16-20
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Carriers for chronic granulomatous disease (CGD) and patients with lupus erythematosus (LE) share several characteristics: They are mostly females, they reduce nitroblue tetra-zolium (NBT) poorly in their neutrophils, and, in some cases, they have similar skin lesions. We thus investigated 19 female LE patients for the presence of laboratory findings characteristic of the carrier state for CGD. None of these patients turned out to have the combined abnormality of neutrophil bactericidal activity and neutrophil NBT-reduction that is diagnostic of CGD carrier state in the X-linked form. An increased frequency of CGD carriers among female LE patients thus appears to be unlikely. Why some CGD carriers develop skin lesions typical of LE remains unexplained.
- Subjects :
- Adult
Blood Bactericidal Activity
congenital, hereditary, and neonatal diseases and abnormalities
Neutrophil bactericidal activity
Neutrophils
Granulomatous Disease, Chronic
Chronic granulomatous disease
immune system diseases
hemic and lymphatic diseases
Genetics
medicine
Humans
Lupus Erythematosus, Systemic
Genetics (clinical)
Aged
Sex Chromosomes
Lupus erythematosus
business.industry
Carrier state
Middle Aged
medicine.disease
Immunology
Phagocyte Bactericidal Dysfunction
Female
Abnormality
Skin lesion
business
Subjects
Details
- ISSN :
- 13990004 and 00099163
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical Genetics
- Accession number :
- edsair.doi.dedup.....8a89575bbb32e6032ea0655572c32abe