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Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer's disease scale: development and results from a mapping study
- Source :
- Quality of Life Research, 30, 3, pp. 867-879, Quality of Life Research, 30(3), 867-879. Springer, Cham, Quality of Life Research. Springer Netherlands, Quality of Life Research, Rombach, I, Iftikhar, M, Jhuti, G S, Gustavsson, A, Lecomte, P, Belger, M, Handels, R, Castro Sanchez, A Y, Kors, J, Hopper, L, Olde Rikkert, M, Selbæk, G, Stephan, A, Sikkes, S A M, Woods, B, Gonçalves-Pereira, M, Zanetti, O, Ramakers, I H G B, Verhey, F R J, Gallacher, J, ROADMAP Consortium, Actifcare Consortium, LeARN Consortium, Landeiro, F & Gray, A M 2021, ' Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study ', Quality of Life Research . https://doi.org/10.1007/s11136-020-02670-8, Quality of Life Research, 30, 867-879
- Publication Year :
- 2021
-
Abstract
- Purpose The Quality of Life Alzheimer’s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available. Methods Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error. Results The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset. Conclusions The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.
- Subjects :
- Male
Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1]
Mean squared error
Scale (ratio)
Computer science
Preference based measures
PATIENT
Article
VALIDATION
03 medical and health sciences
0302 clinical medicine
Quality of life
Alzheimer Disease
EQ-5D
PEOPLE
Surveys and Questionnaires
Statistics
medicine
Humans
Dementia
Health related quality of life
030212 general & internal medicine
DEMQOL
Mapping algorithm
ADAPTATION
VERSION
PROXY
Multinomial logistic regression
Estimation
030503 health policy & services
DEMENTIA
Public Health, Environmental and Occupational Health
Statistical model
OUTCOME MEASURES
medicine.disease
Cross-walking
humanities
Quality of Life
Female
0305 other medical science
Algorithms
Subjects
Details
- ISSN :
- 09629343
- Database :
- OpenAIRE
- Journal :
- Quality of Life Research, 30, 3, pp. 867-879, Quality of Life Research, 30(3), 867-879. Springer, Cham, Quality of Life Research. Springer Netherlands, Quality of Life Research, Rombach, I, Iftikhar, M, Jhuti, G S, Gustavsson, A, Lecomte, P, Belger, M, Handels, R, Castro Sanchez, A Y, Kors, J, Hopper, L, Olde Rikkert, M, Selbæk, G, Stephan, A, Sikkes, S A M, Woods, B, Gonçalves-Pereira, M, Zanetti, O, Ramakers, I H G B, Verhey, F R J, Gallacher, J, ROADMAP Consortium, Actifcare Consortium, LeARN Consortium, Landeiro, F & Gray, A M 2021, ' Obtaining EQ-5D-5L utilities from the disease specific quality of life Alzheimer’s disease scale: development and results from a mapping study ', Quality of Life Research . https://doi.org/10.1007/s11136-020-02670-8, Quality of Life Research, 30, 867-879
- Accession number :
- edsair.doi.dedup.....8a8309c910f5c45a2021d66813abccb0