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Impairment of Circulating CD4+CD25+GARP+ Regulatory T Cells in Patients with Acute Coronary Syndrome
- Source :
- Cellular Physiology and Biochemistry, Vol 33, Iss 3, Pp 621-632 (2014)
- Publication Year :
- 2014
- Publisher :
- Cell Physiol Biochem Press GmbH & Co KG, 2014.
-
Abstract
- Background: Atherosclerosis (AS) is an inflammatory and immune disease. Regulatory T cells (Tregs) suppress the activation of T cells and have been shown to play a protective role during the pathogenesis of AS. However, specific markers for Tregs are lacking. Recently, glycoprotein A repetitions predominant (GARP) was discovered as a specific marker of activated Tregs, and we therefore utilized GARP as a specific surface marker for Tregs in the current study. Methods: To assess whether GARP+ Tregs are downregulated in patients with acute coronary syndrome (ACS), we examined CD4+CD25+GARP+ T cell frequencies as well as their associated cytokines and suppressive function. Additionally, we compared GARP expression to that of FOXP3, which may be more sensitive as a marker of activated Tregs in patients with ACS. Results: Patients with ACS demonstrated a significant decrease in circulating CD4+CD25+GARP+ Tregs. Moreover, the suppressive function of Tregs and levels of related cytokines were also impaired in ACS patients compared to those with stable angina (SA) or normal coronary artery (NCA). Additionally, after TCR stimulation, peripheral blood mononuclear cells (PBMCs) from patients with ACS exhibited a decrease in CD4+CD25+GARP+ Tregs. Conclusions: These fnding indicate that circulating CD4+CD25+GARP+ Tregs are impaired in patients withACS. Thus, targeting GARP may promote the protective function of Tregs in ACS.
- Subjects :
- Male
Physiology
T cell
Stimulation
chemical and pharmacologic phenomena
T-Lymphocytes, Regulatory
Peripheral blood mononuclear cell
lcsh:Physiology
Pathogenesis
lcsh:Biochemistry
Immune system
GARP
Humans
Medicine
lcsh:QD415-436
IL-2 receptor
Aged
lcsh:QP1-981
business.industry
T-cell receptor
Interleukin-2 Receptor alpha Subunit
Membrane Proteins
FOXP3
Forkhead Transcription Factors
hemic and immune systems
Regulatory T cells
Middle Aged
Atherosclerosis
medicine.anatomical_structure
Gene Expression Regulation
Immunology
Female
Acute coronary syndrome
business
Subjects
Details
- Language :
- English
- ISSN :
- 14219778 and 10158987
- Volume :
- 33
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cellular Physiology and Biochemistry
- Accession number :
- edsair.doi.dedup.....8a71479f9b25d1b3971f236ef2684940