A multi-centre additive and logistic risk model for in-hospital mortality following aortic valve replacement

OBJECTIVE: To develop a multivariate prediction model for in-hospital mortality following aortic valve replacement. METHODS: Retrospective analysis of prospectively collected data on 4550 consecutive patients undergoing aortic valve replacement between 1 April 1997 and 31 March 2004 at four hospitals. A multivariate logistic regression analysis was undertaken, using the forward stepwise technique, to identify independent risk factors for in-hospital mortality. The area under the receiver operating characteristic (ROC) curve was calculated to assess the performance of the model. The statistical model was internally validated using the technique of bootstrap resampling, which involved creating 100 random samples, with replacement, of 70% of the entire dataset. The model was also validated on 816 consecutive patients undergoing aortic valve replacement between 1 April 2004 and 31 March 2005 from the same four hospitals. RESULTS: Two hundred and seven (4.6%) in-hospital deaths occurred. Independent variables identified with in-hospital mortality are shown with relevant co-efficient values and p-values as follows: (1) age 70-75 years: 0.7046, p 85 years: 2.0339, p