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The relationship between changes in serum myostatin and adiponectin levels in patients with obesity undergoing a weight loss program
- Source :
- BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-9 (2021), BMC Endocrine Disorders
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background An effective strategy for weight loss in patients who are overweight or obese is to reduce body fat mass while maintaining skeletal muscle mass. Adiponectin and myostatin are affected through changes in body composition due to weight loss, and examining their dynamics may contribute to strategies for maintaining skeletal muscle mass through weight loss. We aimed to examine the relationships among myostatin, adiponectin, and body composition, depending on the extent of weight loss, in patients with obesity undergoing a weight loss program. Methods We examined 66 patients with obesity (age: 46.8 ± 14.0 years, body mass index: 34.3 [31.0–38.4] kg/m2) attending a hospital weight loss program. We categorized the patients into two groups, namely an L group (those with a weight reduction of 5% from baseline). All patients underwent blood tests and were assessed for body composition, insulin resistance, adipocytokine and myokine levels, exercise tolerance, and muscle strength at baseline and post-intervention. Results Serum myostatin and adiponectin levels increased post-intervention in both groups. Body weight and %fat decreased, and the rate of lean body mass (%LBM) increased in both groups. Exercise capacity and muscle strength improved in the M group only. Change in (⊿) myostatin correlated with ⊿%fat, ⊿%LBM, and ⊿adiponectin. ⊿adiponectin (β = − 0.262, p = 0.035) was an independent predictor of ⊿myostatin. Conclusions Myostatin and adiponectin might cross-talk and regulate changes in skeletal muscle and fat mass with or without successful weight loss. These findings indicate that evaluating serum myostatin and adiponectin levels in clinical practice could be used to predict the effects of weight loss and help prevent skeletal muscle mass loss.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Weight loss
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Myostatin
Overweight
Body composition
Diseases of the endocrine glands. Clinical endocrinology
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Surveys and Questionnaires
Internal medicine
Myokine
medicine
Humans
Muscle Strength
Obesity
Muscle, Skeletal
Retrospective Studies
Adiponectin
biology
business.industry
Research
Body Weight
Lean mass
General Medicine
Middle Aged
medicine.disease
RC648-665
Exercise Therapy
Weight Reduction Programs
030104 developmental biology
Endocrinology
Adipose Tissue
Exercise Test
Lean body mass
biology.protein
Female
medicine.symptom
business
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 14726823
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Endocrine Disorders
- Accession number :
- edsair.doi.dedup.....8a70e6c2e50b2dc1f563c386d3f56467