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Cleaved but not endogenous secretory RAGE is associated with outcome in acute ischemic stroke
- Source :
- Neurology. 86:270-276
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- To investigate the expression patterns of 2 soluble isoforms of receptor for advanced glycation end-product (RAGE), including endogenous secretory RAGE (esRAGE) and cleaved RAGE (cRAGE), and their associations with outcome in acute ischemic stroke (IS).Acute IS patients (n = 106) and age- and sex-matched controls (n = 150) were recruited. Plasma levels of total soluble RAGE (sRAGE) and esRAGE in patients at48 hours and 48-72 hours after IS and in controls were measured by ELISA. The level of cRAGE was calculated by subtracting the level of sRAGE from that of esRAGE. Poor outcome was defined as modified Rankin Scale score2 at 3 months after stroke.The plasma levels of cRAGE were significantly higher and correlated to those of esRAGE (p0.001). The plasma levels of esRAGE and cRAGE were both significantly higher in IS patients48 hours and 48-72 hours after onset than in controls, but only level of cRAGE at48 hours was independently associated with poor outcome after adjusting for clinical variables (odds ratio 2.44; 95% confidence interval 1.16-5.16; p = 0.019).The plasma level of cRAGE at48 hours after IS, rather than esRAGE, is a significant predictor of acute IS outcome.
- Subjects :
- Male
Gene isoform
medicine.medical_specialty
Time Factors
endocrine system diseases
Receptor for Advanced Glycation End Products
Endogenous Secretory RAGE
030204 cardiovascular system & hematology
Brain Ischemia
RAGE (receptor)
Brain ischemia
03 medical and health sciences
0302 clinical medicine
Glycation
Internal medicine
Outcome Assessment, Health Care
medicine
Humans
cardiovascular diseases
Receptor
Stroke
Acute ischemic stroke
Aged
business.industry
nutritional and metabolic diseases
Middle Aged
medicine.disease
Surgery
Endocrinology
cardiovascular system
Female
Neurology (clinical)
business
human activities
Biomarkers
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....8a6ecd6e1f743257352d9a93283affbd