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Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa
- Source :
- Neuroscience Research. 121:49-53
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The mechanisms of dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) remain unclear, although it is known that the nucleus accumbens (NAc) plays a role in its development. Based on the hypothesis that DDS and levodopa-induced dyskinesia (LID) share a pathophysiological basis, we investigated dendritic spine morphology of medium spiny neurons (MSNs) in the NAc of a rat model of LID, because spine enlargement in MSNs of the caudate/putamen has been proposed to be a morphological hallmark of LID. Spines of NAc MSNs also became enlarged in the LID model. This result suggests that excitatory supersensitivity of MSNs in the NAc is involved in the development of DDS, similar to what occurs in the caudate/putamen in LID.
- Subjects :
- Male
0301 basic medicine
Levodopa
Time Factors
Dendritic spine
Apomorphine
Tyrosine 3-Monooxygenase
genetic structures
Dendritic Spines
Dopamine Agents
Biology
Nucleus accumbens
Medium spiny neuron
Nucleus Accumbens
Statistics, Nonparametric
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Parkinson Disease, Secondary
Rats, Wistar
Oxidopamine
Dopamine dysregulation syndrome
Neurons
Levodopa-induced dyskinesia
Hydroxydopamine
General Neuroscience
Putamen
Medial Forebrain Bundle
General Medicine
medicine.disease
eye diseases
Rats
Disease Models, Animal
030104 developmental biology
Sympatholytics
sense organs
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 01680102
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- Neuroscience Research
- Accession number :
- edsair.doi.dedup.....8a6ce7d31ad2d3b6e40612e1d1cf0a0a