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Construction Noise Induces Hypercoagulability and Elevated Plasma Corticosteroids in Rats
- Source :
- Clinical and Applied Thrombosis/Hemostasis. 20:710-715
- Publication Year :
- 2013
- Publisher :
- SAGE Publications, 2013.
-
Abstract
- Although animals housed for research purposes are strictly monitored for lighting, temperature, and humidity, the acoustic environment receives less attention. In a retrospective study, we investigated the effect of construction-induced noise on coagulation using thromboelastography in a group of healthy control rats. Animals were unintentionally exposed to noise due to construction in the vicinity of the animal care facility where these rats were housed. We compared the results to those of age-, gender-matched nonexposed rats. There was a significant shortening of the reaction (R) time ( P = .009) and a trend toward an increase in coagulation index (CI; P = .09), indicating hypercoagulability. The short R time and increase in CI were correlated with an elevated plasma cortisol and corticosterone, indicating that the hypercoagulability seen in these rats is stress induced. Noise is a stress factor for which animals need to be monitored, particularly if those animals are selected as controls for hemostasis studies.
- Subjects :
- Male
medicine.medical_specialty
Hydrocortisone
Rats, Sprague-Dawley
chemistry.chemical_compound
Corticosterone
Internal medicine
Healthy control
medicine
Animals
Thrombophilia
Blood Coagulation
Coagulation index
medicine.diagnostic_test
business.industry
Construction Industry
Hematology
General Medicine
Stress factor
medicine.disease
Thrombosis
Thromboelastography
Rats
Endocrinology
chemistry
Anesthesia
Hemostasis
Noise, Occupational
Female
business
Noise (radio)
Subjects
Details
- ISSN :
- 19382723 and 10760296
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Clinical and Applied Thrombosis/Hemostasis
- Accession number :
- edsair.doi.dedup.....8a6901068cbfd545b3fb1a7de6e3cde3
- Full Text :
- https://doi.org/10.1177/1076029613483168