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Construction Noise Induces Hypercoagulability and Elevated Plasma Corticosteroids in Rats

Authors :
Sheila P Gordon
Maha Othman
Mazen Toukh
Source :
Clinical and Applied Thrombosis/Hemostasis. 20:710-715
Publication Year :
2013
Publisher :
SAGE Publications, 2013.

Abstract

Although animals housed for research purposes are strictly monitored for lighting, temperature, and humidity, the acoustic environment receives less attention. In a retrospective study, we investigated the effect of construction-induced noise on coagulation using thromboelastography in a group of healthy control rats. Animals were unintentionally exposed to noise due to construction in the vicinity of the animal care facility where these rats were housed. We compared the results to those of age-, gender-matched nonexposed rats. There was a significant shortening of the reaction (R) time ( P = .009) and a trend toward an increase in coagulation index (CI; P = .09), indicating hypercoagulability. The short R time and increase in CI were correlated with an elevated plasma cortisol and corticosterone, indicating that the hypercoagulability seen in these rats is stress induced. Noise is a stress factor for which animals need to be monitored, particularly if those animals are selected as controls for hemostasis studies.

Details

ISSN :
19382723 and 10760296
Volume :
20
Database :
OpenAIRE
Journal :
Clinical and Applied Thrombosis/Hemostasis
Accession number :
edsair.doi.dedup.....8a6901068cbfd545b3fb1a7de6e3cde3
Full Text :
https://doi.org/10.1177/1076029613483168