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Figure S2: Screening with drugs compared with DMSO control. from Identification of a RAS-activating TMEM87A–RASGRF1 Fusion in an Exceptional Responder to Sunitinib with Non–Small Cell Lung Cancer

Authors :
Geoffrey R. Oxnard
Pasi A Jänne
Lynette M. Sholl
Nikhil Wagle
Michael S. Rabin
Daniel B. Costa
Tom Nguyen
Deepa Rangachari
Jiaqi Li
Emily S. Chambers
Suzanne E. Dahlberg
Sasha Kravets
Sarah E. Clifford
Dewey Kim
Yoshihisa Kobayashi
Alissa J. Cooper
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Screening with drugs targeting sunitinib related receptor tyrosine kinases (RTK) or MAPK pathway were performed in PC9TMEM87A-RASGRF1 clone 1. Relative viability compared with control (treated with DMSO) was shown. A modest inhibitory effect was seen for gilteritinib without control osimertinib, suggesting the off-target toxic effect of the drug rather than on-target inhibition.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....8a632bc56561f6194a53b41684539db4
Full Text :
https://doi.org/10.1158/1078-0432.22477763.v1