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Figure S2: Screening with drugs compared with DMSO control. from Identification of a RAS-activating TMEM87A–RASGRF1 Fusion in an Exceptional Responder to Sunitinib with Non–Small Cell Lung Cancer
- Publication Year :
- 2023
- Publisher :
- American Association for Cancer Research (AACR), 2023.
-
Abstract
- Screening with drugs targeting sunitinib related receptor tyrosine kinases (RTK) or MAPK pathway were performed in PC9TMEM87A-RASGRF1 clone 1. Relative viability compared with control (treated with DMSO) was shown. A modest inhibitory effect was seen for gilteritinib without control osimertinib, suggesting the off-target toxic effect of the drug rather than on-target inhibition.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8a632bc56561f6194a53b41684539db4
- Full Text :
- https://doi.org/10.1158/1078-0432.22477763.v1