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Determinations of the inclusion complex between gossypol and β-cyclodextrin
- Source :
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 65:169-172
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Features of the inclusion complex between gossypol (Gos) and beta-cyclodextrin (CD), such as its aqueous solubility, association constant, characteristics in the solid state and crystalline morphology, as well as the stoichiometry of this complex have been determined. The phase-solubility diagram drawn using UV detections belongs to an AN-type. Fluorescence detection and calculation with the modified Benesi-Hidebrond equation provide an 1:2 stoichiometry for the complex. Its apparent stability constant has been determined to be 3,203 M(-1) by fluorescence technique and confirmed by the calculation from UV spectroscopy. X-ray powder diffractions (XRD) and Scanning Electron Microscopy (SEM) observations showed a clear difference in the crystal morphology of the complex from those of both Gos and beta-CD.
- Subjects :
- chemistry.chemical_classification
Cyclodextrins
Cyclodextrin
Surface Properties
Scanning electron microscope
Gossypol
Analytical chemistry
Fluorescence
Atomic and Molecular Physics, and Optics
Analytical Chemistry
chemistry.chemical_compound
Spectrometry, Fluorescence
Ultraviolet visible spectroscopy
X-Ray Diffraction
chemistry
Stability constants of complexes
X-ray crystallography
Microscopy, Electron, Scanning
Spectrophotometry, Ultraviolet
Instrumentation
Spectroscopy
Stoichiometry
Subjects
Details
- ISSN :
- 13861425
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- Accession number :
- edsair.doi.dedup.....8a5f8fdfac976b9f0cf1851617e1609b