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Reconstructing the Disease Model and Epigenetic Networks for MLL-AF4 Leukemia
- Source :
- Cancer Cell. 14(5):345-347
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell , Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L.
Details
- ISSN :
- 15356108
- Volume :
- 14
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cancer Cell
- Accession number :
- edsair.doi.dedup.....8a543c810aeaf736c93f7d7d41973340
- Full Text :
- https://doi.org/10.1016/j.ccr.2008.10.008