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Aurora-A amplification associated with BRCA2 mutation in breast tumours
- Source :
- Cancer Letters. 248:96-102
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n = 20) and non-carriers (n = 41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p = 0.0005). Extensive Aurora-A amplification was also detected on metaphase chromosomes in three breast epithelial cell lines with the same BRCA2 mutation. In addition, significant association was found between Aurora-A amplification and TP53 mutations in non-BRCA2 mutation carrier tumours (p = 0.007). These results suggest that breast tumours with mutations in BRCA2 or TP53 could be promising candidates for Aurora-A targeted treatment.
- Subjects :
- Heterozygote
Cancer Research
endocrine system diseases
DNA Mutational Analysis
Breast Neoplasms
Protein Serine-Threonine Kinases
Biology
Tp53 mutation
Cell Line
BRCA2 Mutation
Breast cancer
Mutation Carrier
Aurora Kinases
Odds Ratio
medicine
Humans
skin and connective tissue diseases
neoplasms
Metaphase
In Situ Hybridization, Fluorescence
BRCA2 Protein
Gene Amplification
Breast tumours
medicine.disease
female genital diseases and pregnancy complications
Oncology
Mutation
Mutation (genetic algorithm)
Cancer research
Fish
Female
Tumor Suppressor Protein p53
biological phenomena, cell phenomena, and immunity
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 248
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....8a4007085893ec148fd17058ec503e5b