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Longitudinal mapping of mouse cerebral blood volume with MRI
- Source :
- NMR in Biomedicine. 19:535-543
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- MRI estimations of cerebral blood volume (CBV), useful in mapping brain dysfunction, typically require intravenous (IV) injections of contrast agents. Transgenically engineered mice have emerged as the dominant animal model with which to investigate disorders of the brain and novel therapeutic agents. The difficulty in gaining IV access in mice prohibits repeated administration of contrast in the same animal, limiting the ability to map CBV changes over time. Here we address this limitation by first optimizing an approach for estimating CBV that relies on intraperitoneal (IP) rather than IV injections of the contrast agent gadodiamide. Next, we show that CBV maps generated with IP or IV injections are quantitatively comparable. Finally, we show that CBV maps generated with IP gadodiamide can be acquired repeatedly, reliably and safely over time. Although this approach has certain limitations, estimating CBV with IP injections is well-suited for mapping the spatiotemporal pattern of brain dysfunction in mice models of disease, and for testing pharmacological agents.
- Subjects :
- Gadolinium DTPA
Pathology
medicine.medical_specialty
Time Factors
Contrast Media
Mice, Transgenic
Mice
Text mining
Animal model
medicine
Animals
Radiology, Nuclear Medicine and imaging
Spectroscopy
Blood Volume Determination
business.industry
Gadodiamide
Brain dysfunction
Blood volume determination
Limiting
Magnetic Resonance Imaging
Cerebrovascular Circulation
Mice, Inbred C57BL
Disease Models, Animal
Cerebral blood volume
Injections, Intravenous
Molecular Medicine
business
Neuroscience
Injections, Intraperitoneal
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 10991492 and 09523480
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- NMR in Biomedicine
- Accession number :
- edsair.doi.dedup.....8a3589e189e7b17209f1efc34388155e