Additional file 1 of Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis

Additional file1. Literature screening methodology, graphical comparisons of in vivo and in vitro responses, and data analysis results. Figure S1. IL-8, IL-6, IL-1β and TNF-α cytokine responses in vitro compared to PMN influx in vivo following exposure to α-quartz. Figure S2. IL-8, IL-6, IL-1β and TNF-α cytokine responses in vitro compared to PMN influx in vivo following exposure to nano-CeO2. Table S1. Data analysis results for in vitro studies. Table S2. Data analysis results for in vivo studies. Table S3. CIs for various BMR applied in BMD analysis. Table S4 Model comparisons for α-quartz using log-log regression analysis. Table S5. Model comparisons for nano-CeO2 using log-log regression analysis.