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Epigenetic Alterations in Pancreatic Cancer Metastasis
- Source :
- Biomolecules, vol 11, iss 8, Biomolecules, Vol 11, Iss 1082, p 1082 (2021), Biomolecules
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Pancreatic cancer is the third leading cause of cancer-related deaths in the United States. Pancreatic ductal adenocarcinoma (PDA) is the most common (90%) and aggressive type of pancreatic cancer. Genomic analyses of PDA specimens have identified the recurrent genetic mutations that drive PDA initiation and progression. However, the underlying mechanisms that further drive PDA metastasis remain elusive. Despite many attempts, no recurrent genetic mutation driving PDA metastasis has been found, suggesting that PDA metastasis is driven by epigenetic fluctuations rather than genetic factors. Therefore, establishing epigenetic mechanisms of PDA metastasis would facilitate the development of successful therapeutic interventions. In this review, we provide a comprehensive overview on the role of epigenetic mechanisms in PDA as a critical contributor on PDA progression and metastasis. In particular, we explore the recent advancements elucidating the role of nucleosome remodeling, histone modification, and DNA methylation in the process of cancer metastasis.
- Subjects :
- 0301 basic medicine
Epigenomics
Carcinogenesis
health care facilities, manpower, and services
pancreatic cancer
Review
Biochemistry
Epigenesis, Genetic
Metastasis
Histones
Mice
0302 clinical medicine
Medicine
2.1 Biological and endogenous factors
Neoplasm Metastasis
Aetiology
Cancer
DNA methylation
biology
Cell Differentiation
Prognosis
QR1-502
Chromatin
Gene Expression Regulation, Neoplastic
Histone
Pancreatic Ductal
030220 oncology & carcinogenesis
Disease Progression
Carcinoma, Pancreatic Ductal
congenital, hereditary, and neonatal diseases and abnormalities
Pancreatic ductal adenocarcinoma
education
Cancer metastasis
Adenocarcinoma
Microbiology
03 medical and health sciences
Rare Diseases
Genetic
Pancreatic cancer
health services administration
Genetics
Nucleosome
biochemistry
Animals
Humans
metastasis
Epigenetics
Molecular Biology
Neoplastic
epigenetics
business.industry
Carcinoma
Human Genome
medicine.disease
Pancreatic Neoplasms
030104 developmental biology
Gene Expression Regulation
Mutation
biology.protein
Cancer research
Biochemistry and Cell Biology
business
Digestive Diseases
Biomarkers
Transcription Factors
Epigenesis
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Biomolecules, vol 11, iss 8, Biomolecules, Vol 11, Iss 1082, p 1082 (2021), Biomolecules
- Accession number :
- edsair.doi.dedup.....8a0e05664c5755adcbe72a21a494dd1a